Monday, 15 July 2013

Researchers Evaluate Combination Rabies/Ebola Vaccine in Primates

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Researchers Evaluate Combination Rabies/Ebola Vaccine in Primates

Ebola virus, a deadly infection first reported in 1976, causes severe hemorrhagic fever – including bleeding, organ failure, and death – in people and nonhuman primates. Continuing outbreaks of Ebola and the virus’ potential for use as a bioterrorism agent have spurred research toward a safe and effective vaccine.

To this end, researchers at NIAID and Thomas Jefferson University developed and recently evaluated a novel Ebola vaccine based on the existing rabies virus vaccine. The scientists tested three versions of the novel vaccine in nonhuman primates, and found that all three produced potent immune responses against both rabies and Ebola. Of those, one version protected 100 percent of primates against challenge with the Ebola virus. The researchers plan to pursue development of this vaccine for potential use in humans and wildlife.

For more information on the study results and future steps, read the NIAID science update at: http://www.niaid.nih.gov/topics/ebolaMarburg/Pages/rabiesVaccEbola.aspx.


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